Welcome reception

Introduction & Meeting Objectives
John Gribben

Update on consensus for the next classification of haematological malignancies

Laurence de Leval

Session 1:  T-cell Leukemia/Lymphoma
Chairs: Laurence de Leval & Francine Foss

 

Special Lecture: T-cell Leukemia/Lymphoma

• Pre-clinical models for precision therapy in TCLs; Francois Lemonnier
• Epidemiology and predictive models of relapse refractory T-cell lymphoma; Salvia Jain
• Aggressive T-cell lymphoma in refractory patients; Francine Foss 
• Epigenetic therapies in PTCLs; Enrica Marchi
• Evolving therapies in TCL (CAR-T, BsAbs, Duvelisib, VALEMETOSTAT & VALENTINE); Pier Luigi Zinzani

 

Roundtable Discussion

Break

Session 2: Session II:  MCL
Chairs: Stephen Ansell & Ann LaCasce

 

• Evolution of  Mantle Cell lymphoma(s):  From Conception to the Current Reality; Elaine Jaffe
• Frontline therapy for MCL – which patient needs which initial regimen?; Michael Wang
• Consolidation after frontline therapy – is autologous stem cell transplantation for MCL a thing of the past?; Ann LaCasce
• Small molecule inhibitors for relapsed MCL – one at a time or all together? Tycel Phillips

 

Roundtable Discussion: Remaining gaps and perspectives

Session 3: Keynote address
Chair & Introduction: John Gribben

Keynote: Capturing and targeting the molecular heterogeneity in diffuse large B-cell lymphoma; Margaret Shipp

 

Roundtable Discussion

Lunch

Session 4: Novel therapies I
Chairs: Jason Westin & Laurie Sehn 

 

Industry Panel Discussion: Simon Rule

• Harmonized criteria for reporting of imaging in CRFs; an industry perspective; TBC

 

Roundtable discussion

 

McAbs and ADC Combinations:

• Brentuximab combinations; Loretta Nastoupil
• Tafasitamab combinations, Laurie Sehn
• Zilovertamab combinations; Philippe Armand 
• Loncastuximab combinations; Juan Pablo Alderuccio
• Polatuzumab combinations; Gilles Salles
• What’s next in Mab’s and ADC’s?; Greg Nowakowski

 

Roundtable Discussion

Break

Session 5: Special Topic: Hodgkin’s Lymphoma
Chairs: Philippe Armand & Rnjana Advani 

 

• Early stage HL; Stephen Ansell
• Advanced stage HL; Ranjana Advani
• 2nd Line treatment; Philippe Armand
• Beyond 2nd line; Alex Herrera
• HL in older adults; Sarah Rutherford
• 1st line therapy in AYA patients with Hodgkin Lymphoma; Anne LaCasce

 

Roundtable Discussion

Day 1 Wrap Up

Session 6: Bispecific antibodies in 1st and 2nd line treatment of FL and LBCL   
Chairs: Martin Hutchings & Elizabeth Budde

 

CD3/CD20 bispecifics in early lines of treatment in FL and LBCL

• Mosunetuzumab; Elizabeth Budde
• Epcoritamab combinations; Lorenzo Falchi
• Glofitamab combinations; Martin Hutchings
• Plamotamab; combinations; Tycel Phillips
• Odronextamab; Steve Ansell
• AZD0486; Sameh Gaballa

 

Roundtable Discussion

 

Bispecific and trispecifics with other formats and targets

• Imvotamab; Andrew Davies
• Future perspectives with bi-and trispecific antibodies; Jason Westin

 

Roundtable Discussion: Future Directions

Break

Session 7: Novel Therapies
Chairs: Laurie Sehn & Alexey Danilov

 

BTK Inhibitors combinations:

• Ibrutinib; Loretta Nastoupil
• Zanubrutinib; Pier Luigi Zinzani
• Acalabrutinib; Krish Patel 
• Pirtobrutinib; Michael Wang

BTK Degaraders: 

• BGB-16673; Meghan Thompson
• ZelebrudoMIDE (NX-2127) & BexobrutiDEG (NX-5948); Alexey Danilov

BTK & BCL-2 inhibitors:

• Novel therapies for Waldenstrom’s Macroglobulinemia; Steve Treon

Roundtable Discussion

 

Lunch

Session 8: Expanding the CAR platform for NHL
Chairs: David Maloney & Cathrine Bollard

Real World Data:

• Liso-cel for DLBCL; Jeremy Abramson
•  Axi-cel; Mazyar Shadman
•  Tis-a-cel; Gilles Salles
•  Future perspectives – where do we go from here? Jason Westin

e-break (15 min)

• Rapcabtagene; Connor Johnson
• Multi-targeted and in vivo CARs; Tanya Siddiqi

 

Roundtable Discussion: CAR-T in the real-World Setting

 

Final Meeting Summary and Conclusions
Chairs: iwNHL Committee